FORM, COMPOSITION AND PACKAGING OF DRUG anastrozol :
Available in tablet form.
Anastrozol - 1 mg.
Other ingredients: titanium dioxide, lactose, macrogol 300, Valium, methylhydroxypropylcellulose, magnesium stearate, sodium starch glycolate,.
PHARMACOLOGICAL EFFECTS OF DRUG anastrozole :
Anastrozol is a highly selective non-steroidal aromatase inhibitor. Aromatase - an enzyme that helps in postmenopausal women conversion of androsten to estrone in peripheral tissues and further to estradiol. Since the reduced level of circulating estradiol, the drug exhibits therapeutic effects in patients found to have breast cancer. In postmenopausal women a daily dose of anastrozol in one milligram can cause a decrease in estradiol levels at eighty percent.
The drug does not exhibit estrogenic, androgenic, progestogenic and activity. Anastrozol at a dose of less than 10 mg per day does not affect the secretion of aldosterone and cortisol.
After oral intake of the drug quickly absorbes from the gastrointestinal tract. Cmax in plasma occurs within two hours (on an empty stomach). Food can be a little slow, but not the level of suction. Minor changes to the speed of absorption are not usually clinically significant effect on the CSS anastrozol in plasma, if taken daily one tablet.
Anastrozol is combined with plasma proteins to forty percent. Approximately ninety-ninety-five percent of the CSS comes after seven days of treatment.
Metabolization of anastrozol occurs by glucuronidation, hydroxylation, N-dealkylation.
Derivation of anastrozol occurs slowly, T1 / 2 - 40-50 hours
DRUG INDICATIONS anastrozol:
Anastrozol is used to treat postmenopausal women for breast cancer.
Patients who test results for estrogen receptors in which the negative, the effectiveness of anastrozol was not found.
Adults take one milligram orally once a day.
For patients who have found light and moderate renal dysfunction and liver, the dosage is not correct.
SIDE EFFECTS OF DRUG anastrozol :
Among the side effects can be observed vaginal dryness. flushing, nausea, vomiting, diarrhea, headache, somnolence, arthralgia, anorexia, rash, fatigue, slight rise in cholesterol reduction of joint mobility.
In cases of vaginal bleeding were observed mainly in patients during the first weeks of anastrozol after discontinuation of previous hormonal therapy. If vaginal bleeding does not stop, it is necessary to pass an additional examination.
The drug is contraindicated during pregnancy, lactation, preserved menstrual function, hypersensitivity to the drug.
DRUG WARNINGS anastrozol:
It is not recommended to use the drug for women in reproductive age. The state of menopause should confirm biochemically in case of doubt in the hormonal status of the patient.
No data on the safety of Arimidex in patients with moderate and severe hepatic impairment or in patients with severe renal impairment (creatinine clearance below 20 ml / min).
Use in Pediatrics
Arimidex is not recommended for children because of its safety and efficacy in this patient group has not been established.
Results of experimental studies
In studies on laboratory animals shows low acute toxicity of Arimidex.
Effects on ability to drive and control mechanisms
In connection with reports of fatigue and sleepiness associated with taking Arimidex is recommended for these symptoms to be careful while driving or moving machinery.
Overdose of the drug anastrozol:
Cases of overdosage have not been described.
Anastrozol can be combined with other drugs, as shown by clinical studies, most likely not lead to clinically important interaction, which is due to cytochrome P450. Since anastrozol is recommended not to take drugs that estrogens, since they reduce the pharmacological effect of anastrozol.
TERMS AND CONDITIONS OF STORAGE MEDICINE anastrozol:
Sould be stored at temperatures not above 30 ° C. Shelf life is three years.
During treatment with Anastrozol you need proper medical supervision. This guide drug Anastrozol is being provided for reference only. Use of the drug without consulting your doctor may harm your health.
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