Ansomone  is a type of sterilization, instant composition of Recombinant Human Growth Hormone (HGH) containing 191 amino acids, derived from the development of E.coli is identical to the natural growth hormone in the residual amino acids and the phenomenon of three-dimensional structure. Ansomone  is indicated in the absence of growth due to endogenous growth hormone deficiency (GHD) and Turner syndrome, and renal failure. Ansomone  can be used to treat wounds during surgery or burns. It has a positive effect for the preservation of human age determination. Our drug manufacturers Ansomone ® certified by GMP sFDA.

NAME OF MEDICINE.
Generic name: Recombinant human growth hormone for injection.
Trade name: Ansomon ®
Actual composition: Recombinant Human Growth Hormone.

DESCRIPTION Ansomone
White permeable instant powder

PHARMACOLOGY AND TOXICOLOGY.
Ansomone ® affects the endogenous human growth hormone. It stimulates growth and differentiation of chondrocytes, cell growth of the cartilaginous framework, growth and differentiation of osteoblast, accelerates growth and improves cushioning the width of the epiphysis. Ansomone ® can accelerate protein synthesis throughout the body, alter the equilibrium state of the Rh-negative nitrogen caused by injury or surgery, to correct hypoproteinemia because of infection or cirrhosis of the liver, stimulates the synthesis of immune globin and proliferation of lymphoid education, macrophages and lymphocytes, increases the ability resistance to infections, stimulates growth, fibroblast and macrophage in the field of burns and surgery, accelerates wound healing, accelerate the synthesis of cardiocytes, improves the contractility of the heart and reduces the consumption of medical oxygen heart to regulate fat metabolism, suppresses serum cholesterol and reduces the density of protein, fils the lack or absence of growth hormone, regulates fat metabolism, osteometabolism, heart function and kidney function in adults.

Pharmacokinetics
The same pharmacological effect can be achieved by introducing under the skin (n / k) or intramuscularly (IM). Despite the fact that the introduction of the skin can lead to high concentrations of growth hormone in plasma, intramuscular injection can also produce the same level of growth factor like insulin. Absorption of growth hormone is relatively slow, with max. Often occurs within 3-5 hours after administration. Purification of growth hormone in the liver and kidneys, the half-life of about 2-3 hours of cleaning. Anabolic phase of growth hormone, evolved along with the urine is almost impossible to measure. All the components of growth hormone in the circulation system exists as a complex form of growth hormone binding proteins, which prolong the half-life of growth hormone.

SIGNS.
Ansomone is indicated for stunting of children due to lack of endogenous growth hormone.

Other features and usage:
-Fat Burning
-Exercise
-Increased energy level
-Priodnyatoe mood
-Creativity
-Increased mental capacity
-Improved immune function
-Protecting cells
-Improves cholesterol profile section
-Rapid wound healing
-Improves sexual libido
-Improves bone strength

APPLICATION.
2 ml of sterile water to reconstitute dissolve should be introduced across the wall, then screw the bubble soft rotating motion until the contents until completely dissolves, should not be greatly shaken.
Recommended dosage of Ansomone ® for the treatment stops the growth of children: introduction to 0.1 ~ 0.5 U / kg subcutaneously daily for three months to three years. Regimen can be modified at the discretion of the physician.
Recommended dosage of Ansomone ® for the treatment of severe burns: 0,2 ~ 0,14 U / kg subcutaneously daily for two weeks.

SIDE EFFECTS. Growth hormone can cause temporary hyperglycemia, it can be restored when the introduction took place or ended. Side effects occur in 1% of children with impaired growth in the clinical examination. Common side effects are manifested in the form of slack pain, tingling, swelling of the injection and peripheral edema, pain in the joints. All of these side effects often occur early in treatment and are allowed, as well as temporary. Long-term and high dose administration of recombinant human growth hormone may lead to an increase in antibodies in some patients. The concentration of antibodies can sometimes rise up to 2 ml / l, which may affect the therapeutic efficacy.

CONTRAINDICATIONS.
1. Ansomone ® can not taken by patients whose epiphysis had been closed.
2. Ansomone ® should not be taken by patients with cancer with active neoplasia. Growth hormone therapy should be discontinued in case of neoplasia.

PRECAUTIONS
2. Diabetes drug dosage of anti-glucourea should be regulated during treatment with recombinant human growth hormone.
3. For patients whose growth hormone deficiency caused by a brain tumor or brain injury, it is necessary to carefully monitor the development and potential possibility of recurrence of disease.
4. Thyroid function should be checked regularly because clinical hypothyroidism may occur in some patients during treatment with recombinant human growth hormone. For those suffering from hypothyroidism to add thyroid hormone to consolidate the therapeutic effect of treatment with recombinant human growth hormone.
5. Handle should be followed in case of Charcot's syndrome during treatment with recombinant human growth hormone, as patients suffering from diseases of the endocrine system (including growth hormone deficiency) have a metal plate epiphysis of the femur is relatively easy to separate. 6. Growth hormone can lead to oversupply of insulin, you should pay attention to this in the case of glucose intolerance.
7. Prohibited from overdose with recombinant human growth hormone, a single injection of recombinant human growth hormone in excess of the norm may lead to low blood sugar and change to high blood sugar. Long-term overdose of recombinant human growth hormone can cause acromegaly.
8. In the injection site may occur in the event of changes in lipodystrophy.

APPLICATION

Pregnant women and women of childbearing age
Not recommended for pregnant women and women of childbearing age for treatment with recombinant human growth hormone.

APPLICATION IN PEDIATRICS
The use of recombinant human growth hormone is similar to its use in adults in pharmacology, toxicology and pharmacokinetics of recombinant human growth hormone is safe for use in pediatrics.
Response to treatment with recombinant human growth hormone can be inhibited by glucocorticoid so that the dose of hydrocortisone may be less than 10 ~ 15 mg / m surface of the body during treatment with recombinant human growth hormone. The simultaneous use of steroid during treatment with recombinant human hormone accelerates growth.

OVERDOSAGE
No evidence of drug overdose of recombinant human growth hormone overdose may cause some side effects such as hypoglycemia in the early development hyperglycemia. Long-term overdose of recombinant human growth hormone can cause acromegaly.