Vitamin C 1000

International name:
Ascorbic Acid

Group Affiliation:
Vitamin

Description of the active substance (INN):
Ascorbic acid
Regulates immunological reactions (activates the synthesis of antibodies, the C3 component of complement, interferon), promotes phagocytosis and increases resistance to infections. Inhibits the release and accelerates the degradation of histamine, which inhibits the formation of Pg and other mediators of inflammation and allergic reactions. At low doses (150-250 mg / day orally) improves the function of complexing with deferoxamine therapy of chronic intoxication with Fe, which leads to increased excretion of the latter.
Vitamin C is an antioxidant that is essential for growth and tissue repair and strengthen the body's defenses, it also promotes the synthesis of anti-stress hormones and interferon. Vitamin C increases iron absorption, it is necessary for collagen formation, protects against blood clots. It also reduces cholesterol and helps to normalize blood pressure, prevents the development of atherosclerosis. Vitamin C protects the body from the harmful effects of sulfur pollution, helps prevent cancer, infections, strengthens the immune system. The drug prolonges the action of C in 1000, its effective assimilation is provided by the gradual entry into the body. Each tablet has a special coating that ensures the release of its contents only if it enters the intestines. C 1000 and the drug can be used even by those whose stomach is sensitive to vitamin C.
That is not an exhaustive list of diseases in which the recommended intake of vitamin C: asthma, atherosclerosis, cancer, fungal diseases, eye diseases, colds, flu, diabetes, eczema, fatigue, inflammation, inflammation of the division, skin diseases, wounds and weakened immune system.

Uses:
Hypo-and avitaminosis C, and the state increased need for ascorbic acid - the period of artificial feeding and rapid growth, unbalanced diet, parenteral nutrition, hard work, the period of convalescence after serious diseases, scurvy, alcoholism, burn disease, prolonged chill, long fever , hyperthyroidism, chronic infections, gastrointestinal diseases (persistent diarrhea, small bowel resection, peptic ulcer, gastrectomy), smoking, prolonged stress, postoperative, trauma, tuberculosis, pregnancy (especially in plural, on the background of nicotine or drug dependence), lactation . Chronic drug intoxication Fe. Idiopathic methemoglobinemia. In laboratory practice: for labeling of red blood cells (together with sodium chromate Cr51).

Contraindications:
Hypersensitivity. Diabetes mellitus, lack of glucose-6-phosphate dehydrogenase, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oksaloz, nephrolithiasis.

Side effects:
CNS: during fast / in the introduction - dizziness, fatigue. From the digestive system: ingestion - GI irritation. Allergic reactions: skin rash, flushing of the skin. Laboratory findings: thrombocytosis, gipneutrophilic leukocytosis, hypokalemia. The intensive use of chewable tablets or absorption of oral dosage forms can cause damage to the tooth emali.

Dosage:
Inside, after a meal. To prevent hypovitaminosis C: adults - 50-100 mg / day for children - 25-75 mg / day during pregnancy and lactation - 300 mg / day for 10-15 days, then 100 mg / day. With the purpose of treatment: children - 50-100 mg 2-3 times a day, adults - 50-100 mg 3-5 times daily for 2 weeks. The powder used for making drinks - about 1 g (1 / 3 tsp) to 1 liter of water (juice). V / m, a / c, at 50-150 mg (1-3 ml 5% solution), for poisoning - to 3 g (60 ml), maximum single dose - 200 mg daily - 1 g for children - 50 -100 mg / day.

Cautions:
Foods rich in ascorbic acid: citrus, herbs, vegetables (peppers, broccoli, cabbage, tomatoes, potatoes). When storing foods (including long-term freezing, drying, salting, pickling), cooking (especially in copper pots), chopping vegetables and fruits in salads, cooking sauce is a partial destruction of ascorbic acid (for heat treatment - up to 30-50%). In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones it`s necessary to monitor renal function and blood pressure. With prolonged use of large doses may depression of pancreatic insular apparatus, so the treatment process it must be regularly monitored. In patients with a high content of iron in the body should be used ascorbic acid in minimal doses. Now consider unproven efficacy of ascorbic acid for the prevention of cardiovascular disease and certain cancers. Ascorbic acid is not recommended if you have gum infections, haemorrhagic phenomena, hematuria, hemorrhage in the retina, disorders of the immune system, depression not related to deficiency of vitamin C. The product is not considered effective in treating anemia, acne vulgaris, asthma, infertility , atherosclerosis, peptic ulcers, tuberculosis, schizophrenia, dysentery, connective tissue, skin ulcers, hay fever, fractures, drug intoxication, hypothermia general, to prevent thrombosis. Appointment of ascorbic acid in patients with rapidly proliferating rapidly and metastatic tumors may increase during the process .Ascorbic acid as a reducing agent may distort the results of various laboratory tests (blood levels of glucose, bilirubin, activity of "liver" enzymes and LDH). 

Interaction:
Enhances intestinal absorption of drugs Fe (converts ferric iron to ferrous) can increase the excretion of iron, while the use of deferoxamine. Reduces the effectiveness of heparin and indirect anticoagulants. ASA, oral contraceptives, fresh juices and alkaline water reduces the absorption and assimilation. While the use of aspirin increases urinary excretion of ascorbic acid and reduced elimination of ASA. ASA reduces the absorption of ascorbic acid by about 30%. Increases the risk of crystalluria in the treatment of salicylates and sulfonamides short-acting, slow kidney excretion of acid increases the excretion of drugs, having an alkaline reaction (including alkaloids), reduces blood levels of oral contraceptives. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. HP quinoline series, CaCl2, salicylates, corticosteroids for prolonged use depletes reserves of ascorbic acid. When applied simultaneously reduces chronotropism isoprenaline. With prolonged use or used in high doses may interfere with the interaction of disulfiram-ethanol. In high doses, increases the excretion by the kidneys and primidone increase the excretion of ascorbic acid in the urine. Reduces therapeutic effects of antipsychotic drugs (neuroleptics) - derivatives of phenothiazine, tubular reasorbtsiyu amphetamine and tricyclic antidepressants.